Email this article Peran Nutrasetikal Galohgor dalam Mempertahankan Berat Badan dan Menurunkan Glukosa Darah pada Tikus Diabetes yang Diinduksi Streptozotocin
Abstract
Galohgor merupakan salah satu obat herbal tradisional yang lazim di daerah Bogor, Jawa Barat. Neutrasetikal ini tersusun atas 56 jenis bahan yang komposisinya terdiri dari 38 macam tanaman obat, 5 jenis rempah-rempah, 7 jenis kacang-kacangan dan 6 jenis temu-temuan. Tujuan dari penelitian ini untuk mengetahui efek nutrasetikal Galohgor dalam menurunkan kadar glukosa darah dan menjaga kestabilan berat badan tikus diabetes yang diinduksi Streptozotocin (STZ). Penelitian ini menggunakan desain blok acak, 12 ekor tikus Sprague dawley jantan berumur 6 minggu diinjeksi dengan STZ secara intraperitoneal degan dosis 40 mg/kg berat badan dan diberikan sukrosa 30% secara ad libitum selama 4 minggu (masa induksi diabetes) kemudian dialokasikan secara acak kedalam 3 kelompok kemudian diberi intervensi selama 14 hari dengan perlakuan antara lain ekstrak nutrasetikal Galohgor 0,037 g/kg berat badan (Gal+STZ), metformn 62,5 mg/kg berat badan (Met+STZ), dan kelompok kontrol + STZ (K+STZ). Sebanyak 4 ekor tikus normal (N) tanpa perlakuan pemberian sukrosa dimasukkan kedalam kelompok kontrol normal. Hasil menunjukkan ekstrak nutrasetikal Galohgor (Gal+STZ) mampu menurunkan kadar glukosa darah secara signifikan (p<0,05) dan dapat membantu menjaga berat badan pada tikus diabetes yang diinduksi STZ.
Kata kunci: Galohgor, streptozotocin, glukosa darah, berat badan, diabetes
Abstract
Galohgor is one of the traditional herbal medicinel in Bogor, West Java. The Neutraceutical was prepared from 56 kinds of material consist of 38 medicinal plants, 5 herbs and spices, 7 nuts and 6 rhizomes in composition. The aims of this study was to investigate the effect of Nutraceutical Galohgor in maintenance of body weight and reducing blood glucose on diabetic rats induced by streptozotocin (STZ). The type of this study is randomized block design, a number of 12 male Sprague dawley rats on 6 weeks of age were induced with STZ intraperitoneally with dosage of 40 mg/kg body weight and giving with 30% sucrose ad libitum during 4 weeks (diabetic induction fase) and allocated randomly to three groups and treated for 14 days with i.e . nutraceutical Galohgor extract 0,037 g/kg body weight (Gal+STZ), Metformin 62,5 mg/kg body weight (Met+STZ) and control + STZ (K+STZ) group. Four normal rats were allocated as a normal control (N). Glucose level and body weight was measured every 3 days. The result showed that nutraceutical Galohgor extract (Gal+STZ) helped to maintenance body weight and reduced glucose level in diabetic rats significantly (P<0,05) in diabetic rats induced with STZ.
Key words : Galohgor, streptozotocin, blood glucose, body weight, diabetes
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DOI: http://dx.doi.org/10.17728/jatp.29
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